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The diagnosis of depression follows two (2) years of persistent symptoms of hopelessness, irritability, fatigue and ennui, possibly including suicidal thoughts or attempts. “Major depressive disorder is one of the most common mental disorders in the United States.” After other possibilities are controlled (thyroid, heart conditions, substance abuse, etc.), treatment for depression likely includes medication and psychotherapy; most prescriptions require 4-6 weeks to reach the effective dose. (For unresponsive severe depression, ECT has shown to be highly effective, with few long term side effects.)